As the world witnesses a surge in interest in psychedelics, Ayahuasca has emerged as a cultural phenomenon, drawing thousands from around the globe to Peru in search of spiritual and therapeutic breakthroughs. Unfortunately, the field of psychedelics has been steeped in mysticism and pseudoscience for decades, complicating efforts to assess their true benefits and risks. This conference delves into the rise of Ayahuasca tourism and the broader psychedelic renaissance, inviting participants to explore the promises and pitfalls of these substances through a lens of skepticism, critical thinking and science-based medicine.